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IFN, interferon; IL, interleukin; PDE4, phosphodiesterase-4; TNF, tumor necrosis factor.
References: 1. OTEZLA Summary of Product Characteristics. Stockley Park, Uxbridge, UK: Celgene Europe, Ltd; 2016. 2. Schafer PH, Parton A, Capone L, et al. Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity. Cell Signal. 2014;26(9):2016-2029.
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