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A different way to see psoriatic arthritis


Discover how PDE4 inhibition regulates the immune response in the body, believed to cause inflammation in psoriatic arthritis

About psoriatic arthritis1

Psoriatic arthritis is a systemic inflammatory disorder characterized by stiffness, pain, swelling, and tenderness of the joints and the surrounding ligaments and tendons, and psoriatic skin lesions.1

These manifestations are caused by an immune system that becomes dysregulated. Psoriatic arthritis has a significant negative impact on patient functionality, psychology, and quality of life. In one study, psoriatic arthritis was significantly associated with reduced work productivity.2-5

Many patients are diagnosed with psoriatic arthritis approximately 10 years after initial skin symptoms develop.6

Where can I find more information and support?

Additional PDE4 resources

A video explaining how OTEZLA affects multiple cytokines

Advocacy and education

The European League Against Rheumatism (EULAR)

American College of Rheumatology (ACR)

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)


References: 1. Gottlieb A et al. J Am Acad Dermatol. 2008;58:851‑864. 2. Husted JA et al. J Rheumatol. Aug 2013;40(8):1349-1356. 3. Tillett W et al. Rheumatology (Oxford). 2012;51(2):275-283. 4. Lee S et al. P T. 2010;35(12):680-689. 5. Singh JA et al. J Rheumatol. 2009;36(5):1012-1020. 6. Winterfield LS et al. Ann Rheum Dis. 2005;64 Suppl 2:ii87‑ii90.

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