The OTEZLA® international website

This site is intended for healthcare professionals outside the U.S.

CONSIDER ORAL OTEZLA FOR YOUR PSORIASIS PATIENTS

Oral psoriasis treatment options1
 
OTEZLA
Skilarence®
Methotrexate
Acitretin
Cyclosporine
Treatment considerations
Indicated for PsO and PsAtable-checktable-crosstable-checktable-crosstable-cross
Titration period5 daysUp to 9 weekstable-checkUp to 8 weekstable-cross
No label-required laboratory prescreening or ongoing monitoring*table-checktable-crosstable-crosstable-crosstable-cross
Warnings and precautions
  • -Diarrhea
  • -Nausea
  • -Vomiting
  • -Psychiatric disorders
  • -Severe renal impairment
  • -Pregnancy
  • -Underweight patients
  • -Lactose content
  • -Decreased blood cell counts
  • -Opportunistic infections/PML
  • -Severe gastrointestinal disorders
  • -Severe hepatic or renal impairment
  • -Fanconi syndrome
  • -Pregnancy or nursing
  • -Liver function abnormalities
  • -Alcohol use
  • -Active infectious disease
  • -Immunosuppression
  • -Diabetes mellitus
  • -Pregnancy
  • -Significant hematologic abnormalities
  • -Pregnancy category Xa
  • -Severe liver failure
  • -Severe kidney failure
  • -Alcohol use
  • -Lymphomas
  • -Skin malignancy
  • -Infections (including opportunistic)
  • -Renal toxicity
  • -Hepatoxicity
  • -Hypertension
  • -Hyperkaelemia
  • -Neurotoxicity
  • -Pregnancy
  • -Alcohol use

aPregnancy category X (contraception starting 1 month before treatment and 2-year wait period after cessation to become pregnant).

*Regular monitoring is recommended for patients who are underweight at the start of treatment.

Reference:

  1. Data on file, Amgen Inc.
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