The OTEZLA® international website

This site is intended for healthcare professionals outside the U.S.


Sustained improvement in scalp psoriasis up to 1 year1,a,b

aESTEEM 2 study. Data as observed; includes patients who were randomized to OTEZLA 30 mg BID or placebo at baseline, were PASI-50 responders at week 32, and who continued to receive OTEZLA 30 mg BID up to week 52.

bAt week 16, ScPGA score of 0 (clear) or 1 (minimal) achievement was significantly greater with OTEZLA 30 mg BID (40.9%, 72/176) vs placebo (17.2%, 16/93); P < 0.0001; FAS, LOCF.

OTEZLA clears or minimizes scalp psoriasis1

See the OTEZLA difference

Real patients, real pictures.


Week 16

Individual results may vary.

*Among patients with moderate to very severe scalp psoriasis at baseline (ScPGA score ≥3; n = 269/411, 65.5%).

Photos taken from the ESTEEM clinical trial program, which evaluated OTEZLA 30 mg BID in patients with active plaque psoriasis.

BID, twice daily; ESTEEM, Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis; FAS, full analysis set; LOCF, last observation carried forward; PASI, Psoriasis Area and Severity Index; ScPGA, Scalp Physician Global Assessment.


Significant and sustained improvement in scalp psoriasis2,3,a

aLIBERATE study. mITT, LOCF. Includes patients with ScPGA ≥3 (moderate or greater) at baseline. Response at week 16 and week 104 was determined using the LOCF methodology. Week 104 analysis includes patients who entered the apremilast extension phase and were treated in the phase.

bP = 0.0458, OTEZLA vs placebo.

Scalp response was sustained for up to 2 years with OTEZLA3

 BID, twice daily; BL, baseline; DLQI, Dermatology Life Quality Index; ESTEEM, Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis; VAS, visual analogue scale.


  1. Crowley J, Gooderham M, Wasel N, et al. Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients With Nail, Scalp, and Palmoplantar Psoriasis: 52-Week Results From the ESTEEM 2 Trial. Presented at: the 73rd Annual Meeting of the American Academy of Dermatology; March 20-24, 2015; San Francisco, CA.
  2. Reich K, Gooderham M, Green L, et al. The efficacy and safety of apremilast, etanercept and placebo in patients with moderate-to-severe plaque psoriasis: 52-week results from a phase IIIb, randomized, placebo-controlled trial (LIBERATE). J Eur Acad Dermatol Venerol. 2017;31(3):507-517.
  3. Reich K, Gooderham M, Bewley A, et al. Safety and efficacy of apremilast through 104 weeks in patients with moderate to severe psoriasis who continued on apremilast or switched from etanercept treatment: findings from the LIBERATE study. J Eur Acad Dermatol Venereol. 2018;32(3):397-402.
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